World renowned from it's wealthy history and prominence in film and television, Nob Hill provides visual inspiration while inducing perspiration. Perched on top, Grace Cathedral is enjoyed by tourists and locals alike.
Uphill from Chinatown, North Beach, Downtown and the Civic Center - the Cable Cars run from the latter two. The excellent Cable Car Museum is worth a peak as well.
Wikipedia: http://en.wikipedia.org/wiki/Nob_Hill