The primary mode of public transportation for most areas of San Francisco - BART and the Muni Metro are faster and more frequent, but sparse in coverage.
Deriding Muni is a local past time, but the system usually works if not quickly.
Some buses have bike racks, some not, or they're full... but hey, it's a bike - you'll figure something out :)
Most bus shelters have a map of the whole Muni system. Next bus provides live updates, occasionally correlating with reality :)
Website: http://www.sfmta.com
Wikipedia: http://en.wikipedia.org/wiki/San_Francisco_Municipal_Railway